Method and assembly for performing ultrasound surgery using cavitation

ABSTRACT

A method and assembly are provided which use cavitation induced by an ultrasound beam for creating a controlled surgical lesion in a selected treatment volume of a patient. First, a plurality of microbubbles are provided in the treatment volume. Preferably, the threshold for cavitation of microbubbles in the treatment volume is lowered compared with the threshold for cavitation in surrounding tissues. The expected location of the surgical lesion within the treatment volume may be previewed, and then the microbubbles in the treatment volume are cavitated with the ultrasound beam to create the controlled surgical lesion. Preferably, the creation of the surgical lesion at the expected lesion location is then verified. Using the method and assembly of the present invention, the cavitation threshold within the treatment volume is made predictable, and a low frequency ultrasound beam may be used to cavitate the microbubbles within the treatment volume without causing damage to surrounding tissues.

TECHNICAL FIELD

This invention relates to ultrasound surgery, and more particularly to amethod and assembly for the controlled use of cavitation duringdiagnostic and therapeutic ultrasound procedures.

BACKGROUND ART

Compared with other surgical methods, a primary advantage of ultrasoundsurgery is its noninvasive nature. Ultrasound allows diagnostic andtherapeutic procedures to be accomplished either wholly from meansexternal to the body, or with minimal dependence on procedures no moreinvasive than current laproscopic techniques. Being noninvasive, thecost advantages, both in hospital stay and in surgical preparation time,are readily apparent. In addition, the lack of cosmetic disfigurementand risk of infection are both significant advantages for ultrasoundprocedures.

Ultrasound can be utilized for diagnostic imaging, wherein an ultrasoundtransducer is used to generate ultrasonic waves which are directed at aregion of interest in a patient. The transducer then receives reflectedultrasonic waves from the region and converts the received waves intoelectrical signals from which an image is generated. Ultrasound has alsobeen used in various therapeutic applications. One such application,thermally-based ultrasound surgery, involves applying ultrasonic wavesto a targeted treatment volume, such as a tumor, in order to heat thetreatment volume and create a lesion. An example of such an applicationcan be found in U.S. Pat. No. 5,694,936 issued to Fujimoto et al.Another application of therapeutic ultrasound is in the treatment ofvascular thrombosis as seen, for example, in U.S. Pat. No. 5,648,098issued to Porter. Unfortunately, the otherwise beneficial results ofboth diagnostic and therapeutic ultrasound procedures are often madeunpredictable by the phenomenon of acoustic cavitation.

Acoustic cavitation is a term used to define the interaction of anacoustic field, such as an ultrasound field, with bodies containing gasand/or vapor. This term is used in reference to the production of smallgas bubbles, or microbubbles, in the liquid. Specifically, when anacoustic field is propagated into a fluid, the stress induced by thenegative pressure produced can cause the liquid to rupture, forming avoid in the fluid which will contain vapor and/or gas. Acousticcavitation also refers to the oscillation and/or collapse ofmicrobubbles in response to the applied stress of the acoustic field.

The induced oscillation of microbubbles can generally be categorized asnoninertial cavitation or as inertial cavitation. Noninertial cavitationappears at very low acoustic pressure amplitudes, as soon asmicrobubbles are present in a tissue. In noninertial cavitation, thewalls of the microbubbles oscillate at the frequency of the ultrasoundfield generally without damaging surrounding cells, but considerablydisturbing ultrasound transmission by reflecting or scattering incidentwaves. Inertial cavitation appears rather suddenly at higher incidentpressures, thus defining a cavitation onset threshold. In inertialcavitation, microbubbles expand to reach a critical size after which thecollapse is driven by the inertia of the surrounding fluid, thus theterm “inertial” cavitation. Microbubble size is a determining factor inthe degree of response to the ultrasound field, such that microbubblesare highly resonant oscillators at certain drive frequencies.Microbubble oscillation can be sufficiently violent to producemechanical or thermal damage on surrounding tissue, thereby creatinglesions.

In current practice, significant steps are usually taken to avoidcavitation, as described in U.S. Pat. No. 5,573,497 issued to Chapelon.Typically, cavitation is only permitted where it can be very carefullycontrolled and localized, such as at the end of a small probe orcatheter as in U.S. Pat. No. 5,474,531 issued to Carter. The primaryreason for avoiding cavitation is that thresholds for inducingcavitation of microbubbles are unpredictable due to the diversity ofmicrobubble sizes and quantities in different tissues. Uncontrolledcavitation hinders the penetration of ultrasonic waves into tissue, andcan lead to uncontrolled tissue destruction outside the intendedtreatment volume. As a result, surgical protocols have been formulatedwhich attempt to increase cavitation onset thresholds in most diagnosticand therapeutic applications.

Cavitation occurs more easily at low frequencies of ultrasoundtransmission, with the cavitation threshold increasing as the frequencyof ultrasonic waves is increased. Therefore, the predominant method ofcontrolling cavitation during ultrasound procedures has been to utilizehigh frequency ultrasonic waves, as disclosed, for example, in U.S. Pat.No. 5,601,526 issued to Chapelon et al. and in U.S. Pat. No. 5,558,092issued to Unger et al. However, this approach is not without drawbacks,as high frequency ultrasound cannot penetrate as far in soft tissue orthrough bone. In addition, high frequency ultrasound often has thedetrimental effect of excessively heating tissues located between theultrasound transducer and the intended treatment volume.

DISCLOSURE OF INVENTION

Contrary to past approaches, it is an object of the present invention toprovide a method and assembly for performing ultrasound surgery whichuses, instead of avoids, cavitation for diagnostic and therapeuticultrasound procedures.

It is a further object of the present invention to provide a method andassembly for performing ultrasound surgery which makes cavitationthresholds predictable.

It is another object of the present invention to provide a method andassembly for performing ultrasound surgery which creates a controlledlesion within an intended treatment volume.

It is a further object of the present invention to provide a method andassembly for performing ultrasound surgery which utilizes low frequencyultrasonic waves to create the lesion.

It is another object of the present invention to provide a method andassembly for performing ultrasound surgery which allows for a preview ofthe expected lesion location within a treatment volume.

It is yet another object of the present invention to provide a methodand assembly for performing ultrasound surgery which allows verificationof proper lesion formation within the treatment volume.

Accordingly, a method and assembly are provided which use cavitationinduced by an ultrasound beam for creating a controlled surgical lesionin a selected treatment volume of a patient. First, a plurality ofmicrobubbles are provided in the treatment volume. Preferably, thethreshold for cavitation of microbubbles in the treatment volume islowered compared with the threshold for cavitation in surroundingtissues. The expected location of the surgical lesion within thetreatment volume may be previewed, and then the microbubbles in thetreatment volume are cavitated with the ultrasound beam to create thecontrolled surgical lesion. Preferably, the creation of the surgicallesion at the expected lesion location is then verified. Using themethod and assembly of the present invention, the cavitation thresholdwithin the treatment volume is made predictable, and a low frequencyultrasound beam may be used to cavitate the microbubbles within thetreatment volume without causing damage to surrounding tissues.

The above objects and other objects, features, and advantages of thepresent invention are more readily understood from a review of theattached drawings and the accompanying specification and claims.

BRIEF DESCRIPTION OF DRAWINGS

FIG. 1 is an outline of the method of the present invention;

FIG. 2 is a schematic illustration of an ultrasound assembly utilized inthe method of the present invention;

FIG. 3 is a schematic representation of providing microbubbles in atreatment volume;

FIG. 4 is a schematic representation of the detection of microbubbles inthe treatment volume;

FIGS. 5a and 5 b are schematic representations of the elimination ofmicrobubbles from outside the treatment volume and the size tuning ofmicrobubbles within the treatment volume, respectively, to lower thecavitation threshold of microbubbles in the treatment volume;

FIGS. 6a and 6 b are schematic representations of two different methodsof previewing the expected location of the surgical lesion within thetreatment volume;

FIG. 7 is a schematic representation of the cavitation of microbubblesin the treatment volume to create the surgical lesion; and

FIG. 8 is a schematic representation of the verification of lesionformation within the treatment volume at the expected lesion location.

BEST MODE FOR CARRYING OUT THE INVENTION

The method and assembly of the present invention use cavitation inducedby an ultrasound beam to create a controlled surgical lesion in aselected treatment volume of a patient. In overview, as outlined in FIG.1, the method comprises providing 10 a plurlity of microbubbles in thetreatment volume, and then subsequently the presence of microbubbles maybe detected 12 in the treatment volume. Preferably, the threshold forcavitation of microbubbles in the treatment volume is then lowered 14compared with cavitation thresholds outside the treatment volume. Theexpected location of the surgical lesion within the treatment volume maybe previewed 16, and then the microbubbles in the treatment volume arecavitated 18 with the ultrasound beam to create the controlled surgicallesion. Preferably, the creation of the surgical lesion at the expectedlesion location is then verified 20. This method, which is described ingreater detail below, is carried out using a combined therapeutic anddiagnostic ultrasound assembly 22 as shown in FIG. 2.

FIG. 2 shows an ultrasound assembly 22 in accordance with the presentinvention which includes a therapeutic ultrasound system 24 and adiagnostic ultrasound system 26. In a preferred embodiment, therapeuticultrasound system 24 is a phased array ultrasound system which generallyincludes a microprocessor-based controller 28, a network of drivers 30,an ultrasound array 32, and a phase detection subsystem 34. Array 32 isa specialized source of ultrasound energy and is based on multipleultrasound transducers 36 arranged in a two dimensional array such thateach transducer 36 is driven separately by drivers 30. The number oftransducers 36 in array 32 can vary, and each transducer 36 isseparately driven. Through use of controller 28, drivers 30, and phasedetection subsystem 34, the phase of the ultrasound waves produced byeach transducer 36 can be adjusted to form a highly focused ultrasoundbeam, generally designated at 42, which can be formed at a specificlocation within treatment volume 38. The focused location of ultrasoundbeam 42 is therefore determined by the phase distribution of all oftransducers 36 of array 32. Preferably, array 32 is capable ofgenerating ultrasonic waves at a frequency in the range of about 0.1-10MHz. Further details of preferred therapeutic ultrasound system 24 canbe found in commonly owned U.S. Pat. No. 5,590,657 issued to Cain etal., which is herein incorporated by reference in its entirety. However,it will be understood that other types of therapeutic ultrasound systemsmay be employed in practicing the method of the present invention.

Referring again to FIG. 2, diagnostic ultrasound system 26 generallyincludes a digital controller 44, a signal transmitter 46 and receiver48 controlled by controller 44, a transmit/receive switch 50 to regulatethe direction of signal flow, and a visual display 52. Through switch50, transmitter 46 and receiver 48 communicate with an imagingtransducer 54 to obtain image data for treatment volume 38. Preferably,imaging transducer 54 is capable of generating ultrasonic waves at afrequency in the range of about 2-10 MHz and is located as part oftherapeutic ultrasound system 24 to allow diagnostic feedback fortargeting and response to therapy. Of course, other configurations ofdiagnostic ultrasound system 24 may be implemented in conjunction withthe present invention.

FIGS. 3-8 provide schematic representations of the various stages of themethod of the present invention. Referring first to FIG. 3, to create asurgical lesion in a treatment volume 38 of a patient 40, microbubbles56 are provided in treatment volume 38. Microbubbles 56 may beintroduced into the body in the form of liquid droplets thatsubsequently vaporize, gas-filled bubbles, or other similar substance,such as conventional contrast agents. Microbubbles 56 are typicallyintroduced into a patient 40 intravenously, and may either be injectedsystemically into the patient 40 or locally into the treatment volume38. Alternatively, microbubbles 56 can be created in a selectedtreatment volume 38 using a high intensity ultrasound beam 42 fromtherapeutic ultrasound system 24. As one skilled in the art willrecognize, widely varying amounts of microbubbles 56 may be provided inpracticing the method of the present invention.

Microbubbles 56 are preferably monitored with diagnostic ultrasoundsystem 26 until their presence is detected in selected treatment volume38, as shown in FIG. 4. In a preferred embodiment, more detailedinformation regarding microbubbles 56 is also determined at this stage.As is well known in the art, the emission of ultrasonic energy occurs atharmonics of the incident ultrasound frequency. Utilizing this property,harmonic imaging can show differences in microbubble populations moresubtle than the presence or absence of microbubbles, for example, asdescribed in U.S. Pat. No. 5,540,909 issued to Schutt. Harmonic imagingprovides the opportunity for determining the particular sizedistribution of microbubbles 56 which are present in treatment volume38. Using this information, the appropriate frequency of ultrasound beam42 can be selected to subsequently cavitate that particular sizedistribution, and it may be determined if this frequency would be likelyto produce collateral damage in the surrounding tissues.

In order to create a controlled lesion within treatment volume 38, thecavitation threshold for microbubbles 56 in treatment volume 38 ispreferably lowered compared with the cavitation thresholds in anexternal volume 58, outside treatment volume 38. In the cases wheremicrobubbles 56 are injected or created only in treatment volume 38, thecavitation threshold is already lowered in treatment volume 38 comparedwith external volume 58, since few, if any, microbubbles will exist inexternal volume 58. In instances where microbubbles 56 fill bothtreatment volume 38 and external volume 58, lowering of the cavitationthreshold within treatment volume 38 can be accomplished in twodifferent ways, as depicted in FIG. 5.

A first approach, shown in FIG. 5a, is to eliminate microbubbles 56 fromexternal volume 58. At lower intensities, an ultrasound field will notviolently collapse microbubbles 56, but rather will gently destabilizeor otherwise eliminate the scattering of microbubbles 56 in a medium.Therefore, a low intensity ultrasound beam 42 from either diagnosticultrasound system 26 or therapeutic ultrasound system 24 may be sweptthrough external volume 58 to selectively eliminate microbubbles 56therefrom, thereby isolating treatment volume 38 from surroundingtissues. As a result, treatment volume 38, with its preexistingmicrobubbles 56, will have a much lower threshold for cavitation thanexternal volume 58 during subsequent lesion formation. During this step,as well as in subsequent steps involving cavitation and imaging, theselection of an appropriate ultrasound frequency will depend on both thelocation of treatment volume 38 and the resolution required for theprocedure.

Alternatively, in the embodiment illustrated in FIG. 5b, a preliminary,high intensity ultrasound beam 42 from therapeutic ultrasound system 24may be used to create a population of microbubbles 56′ specific totreatment volume 38, and distinct from any microbubbles 56 withinexternal volume 58. The population of microbubbles 56′ can be made tohave a narrow size distribution which is controlled by selection of theultrasound frequency and drive amplitude. This limited size distributionhas the effect of “tuning” microbubbles 56′ to respond to a certainrelatively narrow band of ultrasound frequencies. In a preferredembodiment, microbubbles 56′ are tailored to oscillate at a lowultrasound frequency, at or below about 500 kHz. Therefore, anappropriate incident frequency for a subsequent ultrasound beam 42 canbe chosen to oscillate microbubbles 56′ at their maximal responsefrequency within treatment volume 38 for controlled lesion formation,without affecting microbubbles 56 in external volume 58 to the point ofcreating damage. The maximal response frequency may or may notcorrespond with linear resonance, since it is known that linearresonance is not the driving frequency of maximal response when usinghigher intensity fields. The above approach may be used in addition toproviding microbubbles 56 exclusively into treatment volume 38, or inaddition to the elimination of microbubbles 56 described with referenceto FIG. 5a.

An important advantage of lowering the cavitation threshold in treatmentvolume 38 is that a low frequency ultrasound beam may be used insubsequent cavitation of microbubbles 56 or 56′. Since cavitation occursmore easily at low frequencies of ultrasound transmission, highfrequency ultrasonic waves have typically been utilized duringultrasound procedures to avoid uncontrolled cavitation, even throughhigh frequency ultrasound cannot penetrate through many bone interfacesand often excessively heats intervening tissues. By lowering thecavitation threshold in treatment volume 38 compared with externalvolume 58, the use of a low ultrasound frequency poses no threat ofuncontrolled cavitation outside treatment volume 38. Therefore, a lowultrasound frequency, preferably at or below about 500 kHz, can beutilized which avoids tissue heating and possibly propagates throughbone interfaces. The use of low frequencies allows therapeuticultrasound system 24 to utilize larger phased array elements,significantly reducing array and driving system costs. Furthermore, theultrasound field need not even be focused or localized if treatmentvolume 38 is the only volume containing microbubbles responsive to a lowfrequency, resulting in greatly simplified and less expensive systemswhich can penetrate into normally inaccessible regions of the body.

Before cavitation, ultrasound assembly 22 may be used to obtain apreview of the expected location of high intensity ultrasound beam 42 byaffecting the microbubbles 56 at sub-lesion beam intensities. Startingfrom FIG. 5a, for example, an ultrasound beam 42 of low, sub-lesionintensity from therapeutic ultrasound system 24 is focused on treatmentvolume 38. The low intensity ultrasound beam 42 will gently destabilizemicrobubbles 56 at its focus, thereby removing the microbubbles 56 toleave a momentary dark spot 60, as depicted in FIG. 6a, on an imagegenerated by the diagnostic ultrasound system 26. Dark spot 60 willindicate the expected location of the high intensity ultrasound beam 42.Perfusion of new blood into treatment volume 38 is then allowed so thatmicrobubbles 56 can refill treatment volume 38 for predictablecavitation in subsequent lesion formation. Re-perfusion time ofmicrobubbles 56 into treatment volume 38 might also indicate bloodperfusion information useful for determining subsequent therapeuticprotocols.

Instead of a low intensity ultrasound beam 42, a higher intensityultrasound beam 42 from therapeutic ultrasound system 24 could be usedfor targeting the desired lesion location. As illustrated in FIG. 6b, ahigh intensity ultrasound beam 42 will cause increased cavitation,generating a bright spot 62, as opposed to dark spot 60, in thediagnostic image. If the high intensity ultrasound beam 42 is left ononly briefly, a lesion will not form, but the expected location of thelesion within treatment volume 38 will be apparent. This alternativeapproach may be useful if microbubble collapse in the whole image field,rather than just within treatment volume 38, is observed at allobtainable low intensities.

Once satisfied with the expected lesion location, microbubbles 56 intreatment volume 38 can be cavitated for lesion formation, as shown inFIG. 7. By using the same phase information for every transducer element36 of therapeutic ultrasound system 24 determined during the previewmethods of either FIG. 6a or 6 b, but by increasing all element driveamplitudes, the high intensity ultrasound beam 42 will focus at thatsame location for lesion formation. As described above, a low frequencyultrasound beam 42 may be used to cavitate microbubbles 56 to create thecontrolled surgical lesion. In the case depicted in FIG. 5b, where atailored population of microbubbles 56′ are created, the frequency ofultrasound beam 42 can be selected to correspond to the maximal responsefrequency of microbubbles 56′ for optimal cavitation effects.

During cavitation, drugs can be delivered and activated within treatmentvolume 38 using microbubbles 56. The drug reagents are encapsulatedwithin a microbubble using an encapsulation medium of a protein, acarbohydrate polymer, or a liposome. The encapsulated drugs are thenactivated or chemically modified through cavitation of microbubbles 56at the specific tissue, organ, or region of interest. For example, incancer treatment, a chemotherapeutic agent could be delivered directlyin the tumor volume. Using the method of the present invention, arelatively inert, and therefore safe, reagent can be injected viamicrobubbles 56 in high concentrations throughout the body, and thenactivated locally where its reactivity or cytotoxicity will only affectthe region exposed to ultrasound. If the activated drugs are highlyreactive and short-lived, then harmful accumulation in critical tissuessuch as the liver, bone marrow, and kidney is avoided.

However, the use of drug delivery in conjunction with the system andmethod of the present invention is not restricted to encapsulation ofthe drug reagents within the microbubble 56. In fact, the administrationof drugs could be as simple as providing an admixture of microbubbles 56and the drug, although the proximity of the drug and the cavitatingmicrobubbles 56 is important. Whether encapsulated or not, there are anumber of biological effects which might be elicited by a therapeuticapplication of ultrasound using microbubbles 56 accompanied by drugs,for example, a reduction in post-lesion bleeding, an enhanced necrosisof cancer cells, DNA uptake for gene therapy, and anti-inflammatoryeffects.

In addition, admixtures of microbubbles 56 comprising populations havingdifferent properties could be utilized with the system and method of thepresent invention. For instance, the response of a particular populationof microbubbles 56 to low, typically diagnostic, ultrasound intensitiescompared with high, typically therapeutic, ultrasound intensities is ofsignificance. Therefore, it would be beneficial to provide an admixtureof microbubbles 56 having a first population that responds primarily tohigh intensity fields, and a second population that responds primarilyto lower intensity fields and can be effectively eliminated from futurehigh intensity applications.

Lastly, microbubbles 56 allow the verification of lesion formation aftertreatment volume 38 has been exposed to the high intensity ultrasoundbeam 42. Once a lesion has been obtained, all significant vasculature inthat area will likely be destroyed since microbubbles 56 are restrictedlargely to blood vessels. Thus, as depicted in FIG. 8, following theintroduction of new microbubbles 56 to the patient 40, treatment volume38 will remain devoid of microbubbles 56 because there will be no bloodflow to carry microbubbles 56 into treatment volume 38. Thereintroduction of microbubbles 56 is monitored with diagnosticultrasound system 26 and, depending on the results, further cavitationmay be undertaken to achieve the desired lesion.

In conclusion, the method and assembly of the present invention usecavitation in a beneficial manner by creating a cavitation threshold inthe treatment volume which is lower than cavitation thresholds insurrounding tissues. Cavitation thresholds are thus made predictable, asituation which almost never pertains in the body naturally, and thesituation which has made cavitation a phenomenon to avoid in priorultrasound procedures. As a result, low frequency ultrasound can be usedto induce cavitation in the treatment without harming surroundingtissues, providing a distinct advantage over other methods of ultrasoundsurgery. The method and assembly of the present invention may be usedfor the localization and treatment of tumors or other malignant ornonmalignant masses in all soft tissue areas of clinical interest.

It is understood, of course, that while the form of the invention hereinshown and described constitutes a preferred embodiment of the invention,it is not intended to illustrate all possible forms thereof. It willalso be understood that the words used are words of description ratherthan limitation, and that various changes may be made without departingfrom the spirit and scope of the invention disclosed.

What is claimed is:
 1. A method for creating a surgical lesion in aselected treatment volume of a patient, the method comprising: providinga plurality of microbubbles in the treatment volume and in a volumeexternal to the treatment volume, the microbubbles having a thresholdfor cavitation; controlling the microbubbles in the external volume tocreate a differential threshold for cavitation between the externalvolume and the treatment volume; and cavitating the plurality ofmicrobubbles in the treatment volume with an ultrasound beam ofsufficient energy at an appropriate frequency to create the surgicallesion in a controlled manner within the treatment volume.
 2. The methodof claim 1, wherein the frequency of the ultrasound beam is a lowfrequency.
 3. The method of claim 1, further comprising lowering thethreshold for cavitation of microbubbles in the treatment volume byproducing a population of microbubbles within the treatment volume whichhave a limited size distribution, so that the microbubbles oscillate ata maximal response frequency.
 4. The method of claim 3, wherein themaximal response frequency is a low frequency.
 5. The method claim 1,wherein controlling the microbubbles in the external volume compriseseliminating microbubbles from the external volume with low intensityultrasound beam.
 6. The method of claim 1, wherein providing theplurality of microbubbles includes injecting the microbubbles into thepatient systemically.
 7. The method of claim 1, wherein providing theplurality of microbubbles includes injecting the microbubbles locallyinto the treatment volume.
 8. The method of claim 1, wherein providingthe plurality of microbubbles includes providing an admixture ofmicrobubbles having populations with differing properties.
 9. The methodof claim 8, wherein providing an admixture of microbubbles includesproviding a first population that responds primarily to high intensityultrasound fields in combination with a second population that respondsprimarily to low intensity ultrasound fields.
 10. The method of claim 1,wherein providing the plurality of microbubbles comprises creating theplurality of microbubbles with a preliminary ultrasound beam.
 11. Themethod of claim 1, further comprising detecting the presence ofmicrobubbles in the treatment volume.
 12. The method of claim 11,wherein detecting the presence of microbubbles in the treatment volumeuses harmonic imaging to determine the particular size distribution ofmicrobubbles in the treatment volume.
 13. The method of claim 1, furthercomprising previewing an expected location of the surgical lesion withinthe treatment volume.
 14. The method of claim 13, wherein previewing theexpected location of the surgical lesion includes directing a lowintensity ultrasound beam at the treatment volume so as to collapsemicrobubbles at the focus of the beam, thereby indicating the expectedlesion location.
 15. The method of claim 13, wherein previewing theexpected location of the surgical lesion includes briefly directing ahigh intensity ultrasound beam at the treatment volume to causeincreased cavitation of the microbubbles, thereby indicating theexpected lesion location.
 16. The method of claim 1, wherein theultrasound beam is focused.
 17. The method of claim 1, wherein theultrasound beam is unfocused.
 18. The method of claim 1, whereinproviding the plurality of microbubbles includes providing an admixtureof microbubbles and drugs.
 19. The method of claim 1, wherein cavitatingthe microbubbles releases drugs encapsulated therein within thetreatment volume.
 20. The method of claim 1, further comprisingverifying the creation of the surgical lesion at an expected lesionlocation.
 21. The method of claim 20, wherein verifying the creation ofthe surgical lesion includes providing new microbubbles in the treatmentvolume and monitoring the presence or absence thereof at the expectedlesion location.
 22. The method of claim 1, wherein controlling themicrobubbles in the external volume includes reducing the cavitationpotential in the external volume compared with the treatment volume. 23.A method for using cavitation induced by an ultrasound beam to create acontrolled surgical lesion in a selected treatment volume of a patient,the method comprising: providing a plurality of microbubbles in thetreatment volume and in a volume external to the treatment volume, themicrobubbles having a threshold for cavitation; detecting the presenceof microbubbles in the treatment volume; controlling the microbubbles inthe external volume to create a differential threshold for cavitationbetween the external volume and the treatment volume; previewing anexpected location of the surgical lesion within the treatment volume;cavitating the microbubbles in the treatment volume with the ultrasoundbeam to create the controlled surgical lesion; and verifying thecreation of the surgical lesion at the expected lesion location.